This Is Your Brain On LSD

Published April 15, 2016
Updated July 2, 2019

This incredible video shows you LSD's effects on the human brain like never before. You won't believe how powerful this drug truly is.

Turns out your trip might have been in the name of science after all.

Researchers monitoring the neural activity of participants in a new study recently produced the first images of the effects of LSD on the brain — and the results are pretty impressive.

“This is to neuroscience what the Higgs boson was to particle physics,” said David Nutt, professor of neuropsychopharmacology at Imperial College London and senior researcher on the study.

To visualize the acid trips, volunteers were given a 75mcg injection of LSD (lysergic acid diethylamide) rather than dropping it on a piece of paper, as it’s usually done recreationally. Researchers then conducted
brain scans, which showed that their subjects received images from many different regions of the brain, instead of just from the visual cortex (located at the back of head).

The brain scans also revealed “decreased connectivity between the parahippocampus and retrosplenial cortex,” which is caused by the temporary loss of an individual identity, otherwise known as ego dissolution.

According to the study, this discovery suggests that this particular pathway in the brain maintains the “‘self’ or ‘ego’ and its processing of ‘meaning.'”

In other words, when the boundaries between regions of the brain that are usually separated dissolve during an LSD trip, users report often report a feeling of “oneness with the universe.”

Robin Carhartt-Harris, Nutt’s research partner, believes that there are positive consequences of these emotions.

“This experience is sometimes framed in a religious or spiritual way, and seems to be associated with improvements in wellbeing after the drug’s effects have subsided,” he said.

Both psychologists and psychiatrists have been studying how a brain functions on LSD since the 1950s, but after it was first banned by California in 1966 (the rest of the country soon followed) any scientific research into the drug’s potential therapeutic uses abruptly ended.

Nutt concludes that modeling what happens to the brain on LSD could help treat “pathological states” like depression and addiction.

After seeing the effects of LSD, watch what happens to your brain on MDMA. After that, read about these amazing discoveries made while on drugs.

Elisabeth Sherman
Elisabeth Sherman is a writer living in Jersey City, New Jersey. She holds a Master's in writing from Columbia University, and her work has appeared in Food & Wine, The Guardian, Yahoo, BBC, HuffPost, VICE, MSN, and Vulture.
Savannah Cox
Savannah Cox holds a Master's in International Affairs from The New School as well as a PhD from the University of California, Berkeley, and now serves as an Assistant Professor at the University of Sheffield. Her work as a writer has also appeared on DNAinfo.
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Sherman, Elisabeth. "This Is Your Brain On LSD.", April 15, 2016, Accessed June 15, 2024.