Inside The Tragic Stories Of The Eight U.S. Presidents Who Have Died In Office

Published December 9, 2025
Updated December 10, 2025

The Mysterious Death Of Warren G. Harding At San Francisco’s Palace Hotel

Warren G Harding A President Who Died In Office

Public DomainWarren G. Harding seemingly died of a heart attack, though some believe that the First Lady poisoned him.

Warren G. Harding ascended to the presidency, in part, because of his promise to “Return to Normalcy” after World War I. But his life — and death — were full of plenty of drama.

Elected in 1920, the president didn’t think very highly of his own political abilities. He described himself as “a man of limited talents” and once remarked, “I am not fit for this office and should never have been here.” He had been something of an absentee senator, and a woman named Nan Britton later claimed that Harding had spent more time having an illicit affair with her than worrying about legislation. (A 2015 DNA test confirmed that Britton’s child was Harding’s, as she later claimed.) Harding also spent his time in the Senate writing explicit love letters to another mistress, Carrie Fulton Phillips, in which he often referred to his penis as “Jerry.”

While his love letters were salacious, his presidency was lackluster — and dogged by allegations of corruption. In 1923, Harding and his wife, Florence, decided to embark on a 15,000-mile, cross-country speaking tour dubbed the “Voyage of Understanding” so that Harding could explain his policies to the people of America and set himself up for a reelection campaign in 1924.

But the voyage would turn out to be a fatal one.

Harding, then 57 years old, had been in poor health for some time. PBS reports that he suffered from a condition doctors then understood as neurasthenia, which manifested itself with chronic fatigue, headaches, and other symptoms. Harding had also been warned that his vigorous love affairs were bad for his heart, and the president had shown signs of congestive heart disease for several years. Furthermore, he had started feeling ill during the cross-country journey, though the president blamed his symptoms, including shortness of breath, on stress and food poisoning.

Then, on the night of Aug. 2, 1923, in the presidential suite at San Francisco’s Palace Hotel, Warren G. Harding slumped over and died as his wife was reading him the newspaper.

Florence Harding

Public DomainFlorence Harding’s official White House portrait. Though her husband’s death in 1923 was likely the result of a heart attack, rumors spread in the aftermath that Florence had poisoned him.

The president’s death was originally chalked up to “a stroke of cerebral apoplexy,” though Harding had likely been killed by a heart attack. That said, rumors soon spread that the president’s wife had poisoned him. Some believed that Florence Harding wished to save her husband from the looming Teapot Dome scandal, while others suspected that she wanted revenge because of her husband’s multiple extramarital affairs.

While there is no proof of this, Florence Harding did refuse to let doctors perform an autopsy. Instead, she had Warren G. Harding swiftly laid to rest.

author
Kaleena Fraga
author
A senior staff writer for All That's Interesting since 2021 and co-host of the History Uncovered Podcast, Kaleena Fraga graduated with a dual degree in American History and French Language and Literature from Oberlin College. She previously ran the presidential history blog History First, and has had work published in The Washington Post, Gastro Obscura, and elsewhere. She has published more than 1,200 pieces on topics including history and archaeology. She is based in Brooklyn, New York.
editor
Jaclyn Anglis
editor
Based in Queens, New York, Jaclyn Anglis is the senior managing editor at All That's Interesting, where she has worked since 2019. She holds a Master's degree in journalism from the City University of New York and a dual Bachelor's degree in English writing and history from DePauw University. In a career that spans 11 years, she has also worked with the New York Daily News, Bustle, and Bauer Xcel Media. Her interests include American history, true crime, modern history, and science.
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Fraga, Kaleena. "Inside The Tragic Stories Of The Eight U.S. Presidents Who Have Died In Office." AllThatsInteresting.com, December 9, 2025, https://allthatsinteresting.com/presidents-who-died-in-office. Accessed December 30, 2025.