Inside Project MKUltra, The Covert CIA Program That Experimented With Mind Control

Published October 31, 2017
Updated September 16, 2020
Published October 31, 2017
Updated September 16, 2020

At the height of the Cold War in the 1950s, the CIA carried out the project MKUltra mind-control experiments by dosing scores of helpless subjects with massive amounts of hallucinogens.

Project MKUltra

Getty ImagesA doctor squirts LSD into the mouth of another doctor as part of project MKUltra’s mind-control experiments.

Though they may sound like science fiction and though the CIA tried to deny them for years, the mind-control experiments of project MKUltra were all too real. For more than a decade at the height of the Cold War, CIA researchers abused helpless subjects in some of the most disturbing experiments in history.

Convinced that the Soviet Union had developed mind-control capabilities, the CIA tried to do the same with MKUltra starting in 1953. What followed was an expansive program undertaken across 80 institutions, universities, and hospitals. Each one carried out torturous experiments, including electrocution, verbal and sexual abuse, and dosing subjects with massive quantities of LSD.

What’s more, these experiments often used unwitting subjects who were left with permanent psychological damage.

Unsurprisingly, the CIA conducted the project with the utmost secrecy, even giving it multiple code names. And when it finally ended in the 1970s, most of the records pertaining to it were destroyed on the orders of the director of the CIA himself — that is, all but a small misfiled cache accidentally left intact.

Eventually, those documents and several government investigations helped bring the project to light. Today, the public even has access to some 20,000 documents concerning project MKUltra’s mind-control experiments.

But even this provides only a small window into what is perhaps one of the largest and most heinous government programs and cover-ups in American history.

The Birth Of Project MKUltra At The Height Of The Cold War

Document From MKUltra Mind-Control Experiments

Wikimedia CommonsThe MKUltra program also operated under the cryptonyms MKNAOMI and MKDELTA. The “MK” indicated that the project was sponsored by the Technical Services Staff of the CIA and “Ultra” was a nod to the codename that had been used for classified documents during World War II.

As the Cold War moved into its peak era in the early 1950s, the American intelligence community grew increasingly obsessed with the growing technological advancements of the Soviet Union.

The U.S. government feared, in particular, that it was already falling behind the Soviet Union in regard to novel interrogation techniques. Reports during the Korean War (which later proved erroneous) suggested that North Korean and Soviet forces had developed mind-control capabilities and the U.S. couldn’t let them have that advantage.

Thus, on April 13, 1953, then-director of the nascent CIA Allen Welsh Dulles sanctioned project MKUltra. The program was quickly headed by chemist and poison expert Sidney Gottlieb, who was known in covert circles as the “Black Sorcerer.”

One of Gottlieb’s original goals was to create a truth serum that could be used against Soviet spies and prisoners of war in order to gain intelligence.

Unsurprisingly, perhaps, generating a truth serum proved difficult. Instead, researchers believed that a kind of mind control could be achieved by placing the subject in a heavily altered mental state — typically with the help of wildly experimental drugs.

According to journalist Stephen Kinzer, Gottlieb realized that in order to control the mind, he’d have to wipe it first. “Second, you had to find a way to insert a new mind into that resulting void,” Kinzer explained. “We didn’t get too far on number two, but he did a lot of work on number one.”

In Gottlieb’s own words, project MKUltra’s mind experiments extensively researched extensively how drugs could “enhance the ability of individuals to withstand privation, torture and coercion,” as well as “produce amnesia, shock and confusion.”

A declassified document from 1955 added that MKUltra sought to observe “materials which will cause the victim to age faster/slower in maturity” and “substances which will promote illogical thinking and impulsiveness to the point where the recipient would be discredited in public.”

With these goals in mind, project MKUltra scientists began devising mind-altering experiments with insidious goals — and disastrous results.

How Did Project MKUltra’s Mind-Control Experiments Work?

MKUltra Founder Sidney Gottlieb

CIASidney Gottlieb, the man who oversaw all of the project MKUltra mind-control experiments.

From the beginning, MKUltra’s mind-control experiments were conducted with great secrecy in part because the CIA was well aware of the dubious ethics involved. For secrecy’s sake, the program’s 162 experiments were spread out across multiple cities, college campuses, prisons, and hospitals. In total, 185 researchers were involved — and many of them didn’t even know that their work was meant for the CIA.

In all of these dozens of settings, the primary experimental method often involved administering large quantities of various mind-altering substances in hopes of wiping the human mind in the way Gottlieb wanted to.

Subjects were dosed with LSD, opioids, THC, and the synthetic government-created super hallucinogen BZ, as well as widely available substances such as alcohol. Researchers would also sometimes administer two drugs with opposite effects (such as a barbiturate and an amphetamine) simultaneously and observe their subjects’ reactions, or give subjects already under the influence of alcohol a dose of another drug like LSD.

Aside from drugs, researchers also used hypnosis, often in an effort to create fear in subjects that could then be exploited to gain information. Researchers went on to investigate the effects of hypnosis on the results of polygraph tests and its implications for memory loss.

Donald E Cameron

Wikimedia CommonsDonald E. Cameron, who had been present at the Nuremberg Trials as a psychiatric evaluator for leading Nazi Rudolf Hess, was one of the lead researchers in MKUltra’s mind experiments.

MKUltra participants were also subjected to experimentation involving electroconvulsive therapy, aural stimulation, and paralytic drugs.

Meanwhile, experimenter Donald Cameron (the first chairman of the World Psychiatric Association and the president of the American and Canadian psychiatric associations) drugged patients and repeatedly played tapes of noises or suggestions while they were comatose for long periods of time, hoping to correct schizophrenia by erasing memories in order to reprogram subjects’ minds.

In reality, these tests left his subjects comatose for months at a time and permanently suffering from incontinence and amnesia.

John C. Lilly, a noted animal behaviorist, was also involved in the experiments. For his research in human communication with dolphins, he created the first sensory deprivation flotation tank. MKUltra scientists commissioned the tank to create a sensory-free environment for their subjects to experience their acid trips without the stimuli of the outside world.

With such an arsenal of tools at their disposal, the project MKUltra mind-control experiments succeeded in severely disrupting the human mind, but at great cost to its unwitting subjects.

Who Were The Subjects Of MKUltra?

Electroconvulsive Device Used In Project MKUltra

Wikimedia CommonsAn electroconvulsive machine used during the experiments.

Due to the classified nature of the program, many of the test subjects were unaware of their involvement and Gottlieb admitted that his team targeted “people who could not fight back.” These included drug-addicted prisoners, marginalized sex workers, and both mental and terminal cancer patients.

Some of the subjects of MKUltra were volunteers or paid students. Others were addicts who were bribed with the promise of more drugs if they participated.

Though many of MKUltra’s records were destroyed, there are a few notable documented subjects, including: Ken Kesey, author of One Flew Over the Cuckoo’s Nest; Robert Hunter, a lyricist for the Grateful Dead; and James “Whitey” Bulger, a notorious Boston mob boss.

Some participants were voluntarily vocal about their involvement. Kesey, for example, was an early volunteer and joined the project while he was a student at Stanford University to be observed while taking LSD and other psychedelic drugs.

MKUltra Mind Experiments Subject Ken Kesey

Hulton-Deutsch/Hulton-Deutsch Collection/Corbis via Getty ImagesKen Kesey’s experience with MKUltra in part inspired the writing of his seminal work, One Flew Over The Cuckoo’s Nest.

His experience was, according to him, a positive one and he went on to publicly promote the drug. One Flew Over The Cuckoo’s Nest was also, in part, inspired by his experiences.

Unlike Kesey, however, some participants did not have such positive experiences.

The Undocumented And Damaged Participants

Untold numbers of MKULtra subjects were subjected to chilling abuses in the name of science. In one experiment, an unwitting mental patient in Kentucky was given a dose of LSD every day for 174 consecutive days. Elsewhere, Whitey Bulger reported that he would be dosed with LSD, monitored by a physician, and repeatedly asked leading questions like: “Would you ever kill anyone?” He later suggested that his murderous career as a crime lord was partially brought on by his participation in MKUltra’s mind-control experiments.

Ted Kaczynski In Prison

Internet ArchiveAlleged MKUltra subject Ted Kaczynski in prison, 1999.

Unabomber Ted Kaczynski may also have been involved as a subject in the MKUltra mind experiments conducted at Harvard in the early 1960s.

Another undocumented but suspected participant was the infamous Charles Manson, convicted of ordering a string of brutal Los Angeles murders that shocked the nation in 1969.

According to author Tom O’Neill in Chaos: Charles Manson, the CIA, and the Secret History of the Sixties, Manson not only had people in his circle later connected to the CIA, but the way in which he ran his cult, by doping his followers with a constant flow of LSD, was oddly similar to the kinds of experiments carried out by MKUltra.

Charles Manson Mugshot 1968

Wikimedia CommonsCharles Manson’s 1968 mugshot.

The unsuspecting subjects of MKUltra weren’t all civilians, though; some of them were CIA operatives themselves. Gottlieb claimed that he wanted to study the effects of LSD in “normal” settings — and so he began to administer LSD to CIA officials without warning.

The experiments continued for over a decade even after an Army scientist, Dr. Frank Olson, began to suffer from drug-induced depression and jumped out a 13th-story window right at the project’s outset in 1953.

For those who survived, the fallout of the experiments included things like depression, anterograde and retrograde amnesia, paralysis, withdrawal, confusion, disorientation, pain, insomnia, and schizophrenic-like mental states as a result of the experiments. Long-term effects like these largely went untreated and unreported to authorities.

How Project MKUltra’s Mind-Control Experiments Finally Came To Light

Richard Helms

Bettmann/Contributor/Getty ImagesCIA Director Richard Helms.

In early 1973, in the aftermath of the Watergate scandal, CIA director Richard Helms ordered all MKUltra files destroyed. He feared that all government agencies would be investigated and he would not risk a breach of information on such a controversial topic.

But in 1975, President Gerald R. Ford commissioned an investigation into CIA activities, hoping to eradicate conspiracies within the organization. Two committees spawned from the investigation: the Church Committee of the U.S. Congress, and the Rockefeller Commission.

The overall investigation revealed that Helms had destroyed most of the evidence regarding MKUltra, but that same year, a collection of 8,000 documents were discovered in a financial records building and later released under a Freedom of Information Act request in 1977.

When the remaining documents were made available to the public, the Senate launched a collection of hearings on the ethics of the project later that year.

Survivors soon filed lawsuits against the CIA and the federal government regarding informed consent laws, but not many received any sort of settlement.

Since the documents were revealed, countless shows and movies have been inspired by project MKUltra’s mind-control experiments, most notably The Men Who Stare at Goats, the Jason Bourne series, and Stranger Things.

The government does not deny that the MKUltra experiments took place — but most of what transpired remains a mystery.

Most of the discussion surrounding the experiments today comes from conspiracy theorists. The CIA is adamant that the experiments ceased in 1963 and that all related experiments were abandoned.

Due to the destruction of records, the secrecy surrounding the project, and its various, ever-changing code names, conspiracy theorists aren’t so sure.

Some of them even believe that the experiments are still taking place today. There is, of course, no way to be sure.


After learning about project MKUltra’s mind-control experiments, read up on the CIA’s remote viewing experiments. Then, learn about other terrifying science experiments throughout history.

Katie Serena
Katie Serena is a New York City-based writer and a staff writer at All That's Interesting.