9 X-Files Episodes That Were Based On Real Events

Published June 23, 2015
Updated September 26, 2025

Scully And Mulder

Now that The X-Files revival has been confirmed (we’re getting six new episodes in January of 2016, which even made David Duchovny weep with joy), many have begun their requisite binge-watching of all nine seasons.

What viewers might not have realized the first time around is that many episodes of the hit sci-fi drama were based on real government conspiracies, cover-ups, and paranormal events. Sometimes life is stranger than fiction:

The Erlenmeyer Flask

Real X Files

Source: Wikia

In this episode, Mulder and Scully investigate the case of a woman full of poisonous gas. The woman was in an accident, and when paramedics inserted a needle into her chest, the gas overcame them.

An incident very similar to this occurred in California in the early ’90s. A woman named Gloria Ramirez entered the ER, and when she had blood drawn a strange ammonia-like scent emerged from her body and made the entire emergency room staff ill. She died a few days later, and while it was never determined precisely what caused her to have toxic blood, the woman’s autopsy suggested that she probably had been using dimethyl sulfoxide as a home remedy, which turned into dimethyl sulfate in her blood when she was defibrillated.

Home

X Files Home

Made one of the Files’ most famous episodes because networks refused to air it, “Home” dealt with issues of incest and abuse in a small Pennsylvania town. While the episode’s characters and story were fictional, they were based on the Ward Family. The Ward brothers had notably low IQs, were illiterate and hermits.

When the eldest brother was found dead one morning, his family became the center of a murder trial. The townsfolk maintained that the Ward family — while strange — was harmless. Whether or not they were guilty, the charges were dropped when it was realized the brothers had been coerced into a signing a statement of guilt – which they couldn’t have understood due to their illiteracy.

Space

Space

Source: Wikipedia

Series creator Chris Carter wanted to write this episode after seeing news reports about “the face on Mars.” Exploring the phenomenon of pareidolia, this episode also used a lot of NASA stock footage and capitalized on the disappearance of the Mars Observer around the time of the episode’s production.

In the episode, the human space face was malevolent and murderous. In real life, it was probably just sand.

Duane Barry

Real X Files Duane Barry

Source: Wikipedia

Scully and Mulder spend a considerable amount of time interviewing and investigating the case of Duane Barry, who believes he was abducted by aliens. Medical doctor Scully discovers that his frontal lobe was damaged by a gunshot wound decades earlier, which helps explain Barry’s odd beliefs.

Chris Carter notes that many aspects of Barry’s story and character were taken from the case of Phineas Gage, the man who survived being impaled by a railroad spike only to have his entire personality shift as a result of the brain injury he experienced.

Irresistible

X Files Irresistible

Source: Wikia

One of the series’ most memorable episodes actually had no paranormal elements at all, just a serial killer taunting Scully named Donnie Pfaster. The character was originally written as a necrophiliac, but the network refused to air an episode with that extreme of a plot.

Still, the character was heavily based on Jeffrey Dahmer and the experiences that his hostages reported during their capture, including apparent “shape shifting” by the killer–which was integrated into the episode in a literal sense.

X Files Dahmer

Source: Wikipedia

Our Town

This memorable episode on cannibalism at a chicken factory wasn’t based on a real event (well, that we know of). But the prion disease that people got from ingesting human flesh is based on a real condition: Kuru is a disease that the Fore people of Papua New Guinea are vulnerable to because they practice cannibalism as part of their cultural rituals.

It’s a transmissible spongiform encephalopathy, meaning that when the prion found in humans is ingested, it causes neurological symptoms. The name comes from the Fore word for “shaking”, which is the hallmark symptom of the disease.

Oubliette

Real X Files Stories

The story of a young girl’s stalking and kidnapping was influenced by a kidnapping/murder case that was receiving ample media attention when the episode aired. 13-year-old Polly Klaas had been abducted during a slumber party and was eventually strangled, and California news outlets were in a frenzy to follow the case. Since The X-Files‘ early seasons were filmed in Vancouver, the writers and cast were very aware of the case, and the characters of Lucy and Amy were certainly influenced by Klaas.

Nisei/731

Unit 731

Source: Wikipedia

This two-part episode arc was based on the real Unit 731 of the Japanese Imperial Army. In the mid-90s, many were learning about the atrocities the unit committed during World War II, and Carter felt that the stories of human experimentation during wartime almost constituted a real-life X-File. Unit 731 was not tried for war crimes despite the fact that they subjected humans to biochemical warfare agents, medical torture and rape and forced pregnancies and vivisection.

Many countries, including the United States, agreed not to try the researchers at Unit 731 in exchange for the information and data gathered from their studies, much of which went directly into the development of the U.S. biological warfare program.

Folie à Deux

Real X Files Folie

Source: Wikia

This episode took its title and concept from a real-life psychological phenomenon where two people share a single delusion. The phrase is french for “madness shared by two.” Written by veteran X-Files writer Vince Gilligan (of Breaking Bad fame), this episode was inspired by the terrifying concept of seeing monsters that no one else appears to be able to see.

Tunguska/Terma

Ruined Field

Source: Wikipedia

One of the part of the major episode of the “mytharc,” Tunguska was based on actual events that took place in Russia in 1908. A massive explosion occurred in a forest near the Podkamennaya Tunguska River in Siberia. The explosion continues to perplex scientists because the source of the explosion appeared to be something very large and extraterrestrial that had crashed into the Earth.

Eyewitnesses report seeing an object careering through the sky that morning, but once it hit the ground, there was no trace evidence of anything making impact. Many have termed Tunguska “The Russian Roswell”, believing that it was the country’s most notable extraterrestrial encounter.

The Sixth Extinction/Amor Fati

Real X Files Extinction

The “ancient astronaut” theory played quite heavily into this story arc that started off the series’ sixth season. The theory postulates that aliens have visited Earth and made contact with humans many times in the very distant past of human history, implying that the concept of God was brought to Earth by extraterrestrials. The hypothesis supposes that humans perceived the advanced technology of these ancient aliens as divinity.


Want more on how X Files translates to real life? Check out the 10 most fascinating fringe science experiments! Then, check out some of the most interesting events in world history.

author
Abby Norman
author
Abby Norman is a writer based in New England . Her work has been featured on The Rumpus, The Independent, Bustle, Mental Floss, Atlas Obscura, and Quartz.
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John Kuroski
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Based in Brooklyn, New York, John Kuroski is the editorial director of All That's Interesting. He graduated from New York University with a degree in history, earning a place in the Phi Alpha Theta honor society for history students. An editor at All That's Interesting since 2015, his areas of expertise include modern American history and the ancient Near East. In an editing career spanning 17 years, he previously served as managing editor of Elmore Magazine in New York City for seven years.
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Norman, Abby. "9 X-Files Episodes That Were Based On Real Events." AllThatsInteresting.com, June 23, 2015, https://allthatsinteresting.com/real-x-files. Accessed October 4, 2025.